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Protein Transport into the Endoplasmic Reticulum (Molecular Biology Intelligence Unit) epub download

by Richard Zimmermann


the Endoplasmic Reticulum - eBook ditulis oleh Richard Zimmermann

Protein Transport into the Endoplasmic Reticulum - eBook ditulis oleh Richard Zimmermann. Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that deliv.

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal chaperone BiP act as auxiliary translocation components. Regulation of aberrant protein production, a novel pathway, senses aberrant proteins by monitoring the status of nascent chain interactions during translation and triggers degradation of their mRNA

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The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae. The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum occurs in most eukaryotic cells, but is absent from red blood cells and spermatozoa.

Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and evolutionary related to protein transport into and across the cytoplasmic membrane of eubacteria and archaea. It is based on amino-terminal signal peptides in the precursor polypeptides plus various transport components in cytosol plus ER and can occur either cotranslationally or posttranslationally. The two mechanisms merge at the heterotrimeric Sec61 complex in the ER membrane, which forms an aqueous ng channel.

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Part of the Molecular Biology Intelligence Unit book series (MBIU). Multiple roles of molecular chaperones in protein transport into the mammalian endoplasmic reticulum. The rough endoplasmic reticulum (ER) plays a central role in the biogenesis of most extracellular and many organellar proteins in eukaryotic cells. Therefore, this organelle comprises molecular chaperones that are involved in import, folding/assembly, export, and degradation of polypeptides in millimolar concentrations. 3. Frien M, Jung M, Völzing C et al.

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Molecular Biology of the Cell: Problems Book. Essential Cell Biology. The Biology of Cancer. Case Studies in Cancer. Janeway's Immunobiology. Over the years, protein transport into the ER also has become part of the quest to understand the various roles of molecular chaperones under non-stress conditions and of the ribosomal tunnel exit as the decisive site for molecular triage of nascent polypeptide chains. We provide complimentary e-inspection copies of primary textbooks to instructors considering our books for course adoption.

Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that delivers to its final destination most of what has been transported into the ER, and protein export from the ER that is associated with protein degradation (termed ERAD). Over the years, protein transport into the ER also has become part of the quest to understand the various roles of molecular chaperones under non-stress conditions and of the ribosomal tunnel exit as the decisive site for molecular triage of nascent polypeptide chains.

Protein Transport into the Endoplasmic Reticulum (Molecular Biology Intelligence Unit) epub download

ISBN13: 978-1587063268

ISBN: 1587063263

Author: Richard Zimmermann

Category: Medical Books

Subcategory: Medicine

Language: English

Publisher: CRC Press; 1 edition (August 31, 2009)

Pages: 132 pages

ePUB size: 1293 kb

FB2 size: 1817 kb

Rating: 4.5

Votes: 434

Other Formats: lrf txt mobi mbr

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