The first chapter covers the design of gene targeting vectors for mammalian cells and describes how to distinguish random integrations from homologous recombination. It is followed by a chapter on extending conventional gene targeting manipulations by using site-specific recombination using the Cre-loxP and Flp-FRT systems to produce 'clean' germline.
Gene Targeting: A Practical Approach. How we measure 'reads'. Here we show that targeted deletion of the gene for the β1 subunit leads to a decrease in the calcium sensitivity of BK channels, a reduction in functional coupling of calcium sparks to BK channel activation, and increases in arterial tone and blood pressure. The β1 subunit of the BK channel, by tuning the channel's calcium sensitivity, is a key molecular component in translating calcium signals to the central physiological function of vasoregulation.
Автор: Joyner, Alexandra Название: Gene Targeting A Practical Approach 2/e (Paperback) Издательство: Oxford Academ .
Описание: This book is the final part of a trilogy of volumes covering the practical aspects of ligand interactions, biochemistry, and effector mechanisms of signal-transducing receptors. The book focuses on the measurement of receptor binding interactions both at equilibrium and from the kinetic point of view.
Gene Targeting : A Practical Approach. Practical Approach Series.
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New Biological Books. Gene Targeting: A Practical Approach. Stella Tsirka, "Gene Targeting: A Practical Approach.
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Author: Alexandra L. Joyner
Category: Math and Science
Subcategory: Biological Sciences
Publisher: Oxford University Press; 2 edition (March 9, 2000)
Pages: 312 pages
ePUB size: 1826 kb
FB2 size: 1985 kb
Other Formats: doc txt lrf lit